There is evidence from animal studies with mice bearing pankreas
tumors that MALP-2, when topically applied near the
tumor, significantly enhances the mean survival time of these
mice. There are also first indications from animal experiments
that the spreading of metastases is diminished by MALP-2
application.
It is possible, but has not yet been proven, that MALP-2
acts in at least two ways in these systems: (i) it may activate
cells of the innate immune system such as macrophages and
dendritic cells which are silenced by the tumor, (ii) it may
then act as an adjuvant by affecting these accessory cells
to express co-stimulatory molecules (see below), thus raising
a specific immune response in these mice against their tumor
cells.
Pankreas tumors are particularly rapidly growing and the prognosis
of patients with this type of tumor is not encouraging. A
phase I/II study was performed with patients suffering from
inoperable pancreas carcinomas. Although carried out with
a small number of patients only, the results suggest that
MALP-2, when applied into the remaining tumor during
surgery, extends the life expectancy of these patients.
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